Do Antidepressants Work? In a very detailed analysis published in the British Medical Journal, “Efficacy of Antidepressants in Adults,” two experts concluded “that selective serotonin reuptake inhibitors [i.e. Prozac, Celexa] do not have a clinically meaningful advantage over placebo” and “have not been convincingly shown to affect the long term outcome of depression or suicide rates.” – BMJ 331 (2005):155-157.